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2000 - 2004

Institut für Organische Chemie und Biochemie, Albert-Ludwigs-Universität, Freiburg im Breisgau


Schulz, G.E. (2004). The structure of general porins. In: Bacterial and eukaryotic porins (Benz, R., Ed.), pp. 25-40, Wiley-VCH, Weinheim.

Bannwarth, M., Bastian, S., Heckmann-Pohl, D., Giffhorn, F. & Schulz, G.E. (2004). Crystal structure of pyranose 2-oxidase from the white-rot fungus Peniophora sp. Biochemistry 43, 11683-11690.

Reinert, D.J., Balliano, G. & Schulz, G.E. (2004). Conversion of squalene to the pentacarbocyclic hopene. Chem. Biol. 11, 121-126.

Schelling, P., Claus, M.T., Johner, R., Marquez, V.E., Schulz, G.E. & Scapozza, L. (2004). Biochemical and structural characterization of (South)methanocarbathymidine that specifically inhibits growth of herpes simplex virus type 1 thymidine kinase-transduced osteosarcoma cells. J. Biol. Chem. 279, 32832-32838.

Kessler, D., Rétey, J. & Schulz, G.E. (2004). Structure and action of urocanase. J. Mol. Biol. 342, 183-194.

Ritter, H. & Schulz, G.E. (2004). Structural basis for the entrance into the phenylpropanoid metabolism catalyzed by phenylalanine ammonia-lyase. Plant Cell 16, 3426-3436.

Faller, M., Niederweis, M. & Schulz, G.E. (2004). The structure of a mycobacterial outer membrane channel. Science 303, 1189-1192.


Schulz, G.E. (2003). Transmembrane β-barrel proteins. In: Advances in Protein Chemistry (Rees, D.C., ed.), Vol. 63, 47-70.

Bannwarth, M. & Schulz, G.E. (2003). The expression of outer membrane proteins for crystallization. Biochim. Biophys. Acta, 1610, 37-45.

Ritter, H., Koch-Nolte, F., Marquez, V.E. & Schulz, G.E. (2003). Substrate binding and catalysis of ecto-ADP-ribosyl transferase-2.2 from rat. Biochemistry 42,10155-10162.

Kroemer, M., Merkel, I. & Schulz, G.E. (2003). Structure and catalytic mechanism of L-rhamnulose-1-phosphate aldolase. Biochemistry 42, 10560-10568.

Matern, U., Schleberger, C., Jelakovic, S., Weckesser, J. & Schulz, G.E. (2003). Binding structure of elastase inhibitor scyptolin A. Chem. Biol. 10, 997-1001.

Fritzsche, H.B., Schwede, T. & Schulz, G.E. (2003). Covalent and spatial structure of the cyclodextrinase from Flavobacterium sp. no. 92. Eur. J. Biochem. 270, 2332-2341.

Lenhart, A., Reinert, D.J., Aebi, J.D., Dehmlow, H., Morand, O.H. & Schulz, G.E. (2003). Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase. J. Med. Chem. 46, 2083-2092.

Mosbacher, T.G., Bechthold, A. & Schulz, G.E. (2003). Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes. J. Mol. Biol. 329, 147-157.

Jelakovic, S., Kopriva, S., Süss, K.-H. & Schulz, G.E. (2003). Structure and catalytic mechanism of the cytosolic D-ribulose-5-phosphate 3-epimerase from rice. J. Mol. Biol. 326, 127-135.

Ringler, P. & Schulz, G.E. (2003). Self-assembly of proteins into designed networks. Science 302, 106-109.


Kroemer,M. & Schulz, G.E. (2002). The structure of L-rhamnulose-1-phosphate aldolase (class II) solved by low-resolution SIR phasing and twentyfold NCS-averaging. Acta Crystallogr. sect. D 58, 824-832.

Mueller-Dieckmann, C., Scheuermann, T., Wursthorn, K., Schröder, J., Haag, F., Schulz, G.E. & Koch-Nolte, F. (2002). Expression, purification, crystallization and preliminary X-ray analysis of rat ecto-ADP-ribosyltransferase 2 (ART2.2). Acta Crystallogr. sect. D 58, 1211-1213.

Schulz, G.E. (2002). The structure of bacterial outer membrane proteins. Biochim. Biophys. Acta, 1565, 308-317.

Jelakovic, S. & Schulz, G.E. (2002). Catalytic mechanism of CMP: 2-keto-3-deoxy-manno-octonic acid synthetase as derived from complexes with reaction educt and product. Biochemistry 41, 1174-1181.

Lenhart, A., Weihofen, W.A., Pleschke, A.E.W. & Schulz, G.E. (2002). Crystal structure of a squalene cyclase in complex with the potential anticholesteremic drug Ro48-8071. Chem. Biol. 9, 639-645.

Ringler, P. & Schulz, G.E. (2002). OmpA membrane domain as a tight-binding anchor for lipid bilayers. ChemBioChem 3, 463-466.

Baedeker, M. & Schulz, G.E. (2002). Structures of two histidine ammonia-lyase modifications and implications for the catalytic mechanism. Eur. J. Biochem. 269, 1790-1797.

Milla, P., Lenhart, A., Grosa, G., Viola, F., Weihofen, W., Schulz, G.E. & Balliano, G. (2002). Thiol-modifying inhibitors for understanding squalene cyclase function. Eur. J. Biochem. 269, 2108-2116.

Mueller-Dieckmann, C., Ritter, H., Haag, F., Koch-Nolte, F. & Schulz, G.E. (2002). Structure of the ecto-ADP-ribosyltransferase ART2.2 from rat. J. Mol. Biol. 322, 687-696.

Bannwarth, M. & Schulz, G.E. (2002). Asymmetric conductivity of engineered porins. Protein Engng. 15, 799-804.

Baedeker, M. & Schulz, G.E. (2002). Autocatalytic peptide cyclization during chain folding of histidine ammonia-lyase. Structure 10, 61-67.


Jelakovic, S. & Schulz, G.E. (2001). The structure of CMP: 2-keto-3-deoxy-manno-octonic acid synthetase and of its complexes with substrates and substrate analogues. J. Mol. Biol. 312, 143-155.

Wurth, C., Kessler, U., Vogt, J., Schulz, G. E., Folkers, G. & Scapozza, L. (2001). The effect of substrate binding on the conformation and structural stability of Herpes simplex virus type 1 thymidine kinase. Protein Sci. 10, 63-73.


Wendt, K.-U., Schulz, G.E., Corey, E.J. & Liu, D.R. (2000). Enzyme mechanisms for polycyclic triterpene formation. Angew. Chem. 112, 2930-2952. Angew. Chem. Intl. Edit. 39, 2812-2833.

Kaper, T., Lebbink, J.H.G., Pouwels, J., Kopp, J., Schulz, G.E., van der Oost, J. & de Vos, W.M. (2000). Comparative structural analysis and substrate specificity engineering of the hyperthermostable β-glucosidase CelB from Pyrococcus furiosus. Biochemistry 39, 4963-4970.

Joerger, A.C., Gosse, C., Fessner, W.-D. & Schulz, G.E. (2000). Catalytic action of fuculose-1-phosphate aldolase (class II) as derived from structure-directed mutagenesis. Biochemistry 39, 6033-6041.

Prota, A., Vogt, J., Pilger, B., Perozzo, R., Wurth, C., Marquez, V.E., Russ, P., Schulz, G.E., Folkers, G. & Scapozza, L. (2000). Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine. Biochemistry 39, 9597-9603.

Ziegler, G.A. & Schulz, G.E. (2000). Crystal structures of adrenodoxin reductase in complex with NADP+ and NADPH suggesting a mechanism for the electron transfer of a sequence family. Biochemistry 39, 10986-10995.

Schulz, G.E. (2000). Beta-barrel membrane proteins. Curr. Opin. Struct. Biol. 10, 443-447.

Brix, J., Ziegler, G.A. Dietmeier, K., Schneider-Mergener, J., Schulz, G.E. & Pfanner, N. (2000). The mitochondrial import receptor Tom70: identification of a 25 kDa core domain with a specific binding site for preproteins. J. Mol. Biol. 303, 479-488.

Joerger, A.C., Mueller-Dieckmann, C. & Schulz, G.E. (2000). Structures of L-fuculose 1-phosphate aldolase mutants outlining motions during catalysis. J. Mol. Biol. 303, 531-544.

Pautsch, A. & Schulz, G.E. (2000). High resolution structure of the OmpA membrane domain. J. Mol. Biol. 298, 273-282.

Vogt, J., Perozzo, R., Pautsch, A., Prota, A., Schelling, P., Pilger, B., Folkers, G., Scapozza, L. & Schulz, G.E. (2000). The nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography. Proteins: Struct. Funct. Genet. 41, 545-553.

Rolli, V., Ruf, A., Augustin, A., Schulz, G.E., Ménissier-de Murcia, J. & de Murcia, G. (2000). Poly(ADP-ribose) polymerase: structure and function. In: From DNA damage and stress signaling to cell death: Poly ADP-ribosylation reactions (eds. de Murcia, G. & Shall, S.), pp. 35-79, Oxford University Press, Oxford.

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