Institut für Organische Chemie und Biochemie, Albert-Ludwigs-Universität, Freiburg

1994

Mittl, P.R.E., Berry, A., Scrutton, N.S., Perham, R.N. & Schulz, G.E. (1994). A designed mutant of the enzyme glutathione reductase shortens the crystallization time by a factor of forty. Acta Crystallogr. Sect. D, 50, 228-231.

Schulz, G.E. (1994). Structure-function relationships in porins as derived from a 1.8 Å resolution crystal structure. In: New Comprehensive Biochemistry (J.-M. Ghuysen & R. Hakenbeck, eds.) vol.27, pp.343-352, Elsevier, Amsterdam.

Jung, S., Miranda, E., Ménissier-de Murcia, J., Niedergang, C., Delarue, M., Schulz, G.E. & de Murcia, G. (1994). Preliminary crystallization and X-ray analysis of recombinant chicken poly(ADP-ribose)polymerase catalytic domain overproduced in Sf9 insect cells. J. Mol. Biol. 244, 114-116.

Kreusch, A. & Schulz, G.E. (1994). Refined structure of the porin from Rhodopseudomonas blastica and comparison with the porin from Rhodobacter capsulatus. J. Mol. Biol. 243, 891-905.

Muller, Y.A., Schumacher, G., Rudolph, R. & Schulz, G.E. (1994). The refined structures of a stabilized mutant and of wild-type pyruvate oxidase from Lactobacillus plantarum. J. Mol. Biol. 237, 315-335.

Müller-Dieckmann, H.-J. & Schulz, G.E. (1994). The structure of uridylate kinase with its substrates: geometry of the phosphoryl transfer transition state. J. Mol. Biol. 236, 361-367.

Kreusch, A., Neubüser, A., Schiltz, E., Weckesser, J. & Schulz, G.E. (1994). The structure of the membrane channel porin from Rhodopseudomonas blastica at 2.0 Å resolution. Protein Sci. 3, 58-63.

Mittl, P.R.E. & Schulz, G.E. (1994). The structure of glutathione reductase from Escherichia coli at 1.86 Å resolution: Comparison with the enzyme from human erythrocytes. Protein Sci. 3, 799-809.

Mittl, P.R.E., Berry, A., Scrutton, N.S., Perham, R.N. & Schulz, G.E. (1994). Anatomy of an engineered NAD-binding site. Protein Sci. 3, 1504-1514.

1993

Schulz, G.E. (1993). Bacterial porins: structure and function. Curr. Opin. Cell Biol. 5, 701-707.

Zschocke, P.D., Schiltz, E. & Schulz, G.E. (1993). Purification and sequence determination of guanylate kinase from pig brain. Eur. J. Biochem. 213, 263-269.

Stehle, T., Claiborne, A. & Schulz, G.E. (1993). NADH binding site and catalysis of NADH peroxidase. Eur. J. Biochem. 211, 221-226.

Mittl, P.R.E., Berry, A., Scrutton, N.S., Perham, R.N. & Schulz, G.E. (1993). Structural differences between wild-type NADP-dependent glutathione reductase from Escherichia coli and a redesigned NAD-dependent mutant. J. Mol. Biol. 231, 191-195.

Dreyer, M.K. & Schulz, G.E. (1993). The spatial structure of the class II L-fuculose-1-phosphate aldolase from Escherichia coli. J. Mol. Biol. 231, 549-553.

Weiss,M.S. & Schulz, G.E. (1993). Porin conformation in the absence of calcium; refined structure at 2.5 Å resolution. J. Mol. Biol. 231, 817-824.

Müller, C.W. & Schulz, G.E. (1993). Crystal structures of two mutants of adenylate kinase from Escherichia coli that modify the Gly-loop. Proteins: Struct. Funct. Genet. 15, 42-49.

Muller, Y.A. & Schulz, G.E. (1993). Structure and catalysis of the thiamine- and flavin-dependent enzyme pyruvate oxidase. Science 259, 965-967.

Muller, Y.A., Lindqvist, Y., Furey, W., Schulz, G.E., Jordan, F. & Schneider, G. (1993). The thiamin diphosphate binding fold. Comparison of the crystal structures of transketolase, pyruvate oxidase and pyruvate decarboxylase. Structure 1, 95-103.

Gerstein, M., Schulz, G.E. & Chothia, C. (1993). Domain closure in adenylate kinase: joints on either side of two helices close like neighboring fingers. J. Mol. Biol. 229, 494-501.

1992

Stehle, T. & Schulz, G.E. (1992). Temperature-dependent spacegroup transitions in crystals of guanylate kinase from yeast. Acta Crystallogr. Sect. B, 48, 546-548.

Klein, C., Hollender, J., Bender, H. & Schulz, G.E. (1992). Catalytic center of cyclodextrin glycosyltransferase derived from X-ray structure analysis combined with site-directed mutagenesis. Biochemistry 31, 8740-8746.

Schulz, G.E. (1992). Binding of nucleotides by proteins. Curr. Opin. Struct. Biol. 2, 61-67.

Schulz, G.E. (1992). The induced-fit movements in adenylate kinases. Faraday Discuss. 93, 85-93.

Schulz, G.E., Dreyer, D., Klein, C., Kreusch, A., Mittl, P., Müller, C.W., Müller-Dieckmann, J., Muller, Y., Proba, K., Schlauderer, G., Spürgin, P., Stehle, T. & Weiss, M.S. (1992). Highly ordered crystals of channel-forming membrane proteins, of nucleoside-monophosphate kinases, of FAD-containing oxidoreductases and of sugar-processing enzymes and their mutants. J. Crystal Growth 122, 385-392.

Weiss, M.S. & Schulz, G.E. (1992). Structure of porin refined at 1.8 Å resolution. J. Mol. Biol. 227, 493-509.

Müller, C.W. & Schulz, G.E. (1992). The refined structure of adenylate kinase from Escherichia coli co-crystallized with the inhibitor Ap₅A at 1.9 Å resolution. J. Mol. Biol. 224, 159-177.

Stehle, T. & Schulz, G.E. (1992). Refined structure of the complex between guanylate kinase and its substrate GMP at 2.0 Å resolution. J. Mol. Biol. 224, 1127-1141.

Schulz, G.E. (1992). Structure-function relationships in the membrane channel porin as based on a 1.8 Å resolution crystal structure. In: Membrane Proteins: Structures, Interactions and Models (A. Pullman, J. Jortner & B. Pullman, eds.), Kluwer, Dordrecht, pp. 403-412.

Karplus, P.A. & Schulz, G.E. (1992). The refined three-dimensional structure of glutathione reductase. In: Chemistry and Biochemistry of Flavoenzymes, vol.III (ed. F. Müller), pp. 213-228, CRC-Press, Boca Raton, USA.

1991

Fessner, W.-D., Sinerius, G., Schneider, A., Dreyer, M., Schulz, G.E., Badia, J. & Aguilar, J. (1991). Auf dem Weg zu einem flexiblen Schema diastereoselektiver, enzymatischer Aldoladditionen: L-Fuculose-1-phosphat Aldolasen aus Escherichia coli. Angew. Chem. 103, 596-599. Diastereoselective enzymatic aldol additions: L-rhamnulose and L-fuculose 1-phosphate aldolases from E. coli. Angew. Chem. Internatl. Edit. Engl. 30, 555-558.

Welte, W., Weiss, M.S., Nestel, U., Weckesser, J., Schiltz, E. & Schulz, G.E. (1991). Prediction of the general structure of OmpF and PhoE from the sequence and structure of porin from Rhodobacter capsulatus. Orientation of porin in the membrane. Biochim. Biophys. Acta 1080, 271-274.

Schulz, G.E. (1991). Mechanism of enzyme catalysis derived from crystal structure analyses. In: Protein conformation (CIBA-Foundation Symposium No.161), Wiley, Chichester, pp. 8-27.

Schulz, G.E. (1991). Domain motions in proteins. Curr. Opin. Struct. Biol. 1, 883-888.

Ermler, U., Ghisla, S., Massey, V. & Schulz, G.E. (1991). Structural, spectroscopic and catalytic activity studies on glutathione reductase reconstituted with FAD-analogues. Eur. J. Biochem. 199, 133-138.

Schiltz, E., Kreusch, A., Nestel, U. & Schulz, G.E. (1991). Primary structure of porin from Rhodobacter capsulatus. Eur. J. Biochem. 199, 587-594.

Weiss, M.S., Kreusch, A., Schiltz, E., Nestel, U., Welte, W., Weckesser, J. & Schulz, G.E. (1991). The structure of porin from Rhodobacter capsulatus at 1.8 Å resolution. FEBS Lett. 280, 379-382.

Schulz, G.E. & Ermler, U. (1991). Structural changes on binding FAD and FAD-analogues and on site-directed mutagenesis of glutathione reductase. In: Flavins and Flavoproteins 1990 (eds. B. Curti, S. Ronchi & G. Zanetti), pp. 505-512, de Gruyter, Berlin.

Stehle, T., Ahmed, S.A., Claiborne, A. & Schulz, G.E. (1991). The structure of NADH peroxidase from Streptococcus faecalis 10C1 refined at 2.16 Å resolution. J. Mol. Biol. 221, 1325-1344.

Kreusch, A., Weiss, M.S., Welte, W., Weckesser, J. & Schulz, G.E. (1991). Crystals of an integral membrane protein diffracting to 1.8 Å resolution. J. Mol. Biol. 217, 9-10.

Diederichs, K. & Schulz, G.E. (1991). The refined structure of the complex between adenylate kinase from beef heart mitochondrial matrix and its substrate AMP at 1.85 Å resolution. J. Mol. Biol. 217, 541-549.

Klein, C. & Schulz, G.E. (1991). The refined structure of cyclodextrin glycosyltransferase from Bacillus circulans at 2.0 Å resolution. J. Mol. Biol. 217, 737-750.

Pauptit, R.A., Schirmer, T., Jansonius, J.N., Rosenbusch, J.P., Parker, M.W., Tucker, A.D., Tsernoglou, D., Weiss, M.S. & Schulz, G.E. (1991). A common channel-forming motif in evolutionary distant porins. J. Struct. Biol. 107, 136-145.

Ermler, U. & Schulz, G.E. (1991). The three-dimensional structure of glutathione reductase from Escherichia coli at 3.0 Å resolution. Proteins: Struct. Funct. Genet. 9, 174-179.

Weiss, M.S., Abele, U., Weckesser, J., Welte, W., Schiltz, E. & Schulz, G.E. (1991). Molecular architecture and electrostatic properties of a bacterial porin. Science 254, 1627-1630.

1990

Nitschke, L., Heeger, K., Bender, H. & Schulz, G.E. (1990). Molecular cloning, nucleotide sequence and expression in Escherichia coli of the ß-cyclodextrin glycosyltransferase gene from Bacillus circulans strain no. 8. Appl. Microbiol. Biotechnol. 33, 542-546.

Janes, W. & Schulz, G.E. (1990). The role of the charged groups of glutathione disulfide in the catalysis of glutathione reductase: crystallographic and kinetic studies with synthetic analogues. Biochemistry 29, 4022-4033.

Diederichs, K. & Schulz, G.E. (1990). The three-dimensional structure of the complex between mitochondrial matrix adenylate kinase and its substrate AMP. Biochemistry 29, 8138-8144.

Stehle, T., Ahmed, S.A., Claiborne, A. & Schulz, G.E. (1990). The structure of NADH-peroxidase from Streptococcus faecalis at 3.3 Å resolution. FEBS Lett. 267, 186-188.

Weiss, M.S., Wacker, T., Weckesser, J., Welte, W. & Schulz, G.E. (1990). The three-dimensional structure of porin from Rhodobacter capsulatus at 3 Å resolution. FEBS Lett. 267, 268-272.

Janes, W. & Schulz, G.E. (1990). Synthesis of glutathione analogues with modified ionizable groups for the study of enzyme:ligand interactions. Internat. J. Pept. Prot. Res. 36, 134-138.

Janes, W. & Schulz, G.E. (1990). The binding of the retro-analogue of glutathione disulfide to glutathione reductase. J. Biol. Chem. 265, 10443-10445.

Schulz, G.E., Müller, C.W. & Diederichs, K. (1990). The induced-fit movements in adenylate kinases. J. Mol. Biol. 213, 627-630.

Stehle, T. & Schulz, G.E. (1990). Three-dimensional structure of the complex of guanylate kinase from yeast with its substrate GMP. J. Mol. Biol. 211, 249-254.

Klein, C., Vogel, W., Bender, H. & Schulz, G.E. (1990). Engineering a heavy atom derivative for the X-ray structure analysis of cyclodextrin glycosyltransferase. Protein Engng. 4, 65-67.